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[8] It is also available in the fixed-dose combination medication sitagliptin/metformin (Janumet, Janumet XR)

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Decreased aging, improved performance that are attributable to improved blood pressure control, improved glycemic control, weight loss, increased renal blood flow, restoration of normal glomerular hemodynamics, enhanced autoregulation, and prevention of oxidative injury are potential contributors to reducing cardiovascular events through the kidney-cardiovascular axis [85]